Posted on 21-07-2008
Filed Under (Health) by mike


The SEAS trial will reveal outcomes from a test of the drug Vytorin. Sales have been badly hurt this year due to failure of the drug to cut plaque in neck arteries in a separate trial, called Enhance, whose results were presented in January. SEAS trial will confirm or rebut the earlier tests. Merck and Schering are holding back company earnings financial statements until the SEAS trial is completed.

 

The drugmakers sell Vytorin, as well as Zetia, through a joint venture for treating aortic stenosis, or narrowing of the aorta, the heart’s biggest artery.

High levels of bad cholesterol or LDL indicate that you may be developing atherosclerosis (thickening of the blood vessel walls with fat), making it harder for blood to circulate. The vessels that supply blood to the heart are the coronary arteries. 

In recent years, the spotlight has turned to the use of tocopherols in atherosclerosis as it relates to coronary and peripheral vascular disease. There is good evidence to suggest that vitamin E plays a beneficial role as adjunctive atherosclerosis to alzheimer’s.

Prehypertensive young adults are likely to have arteriosclerosis. A systolic blood pressure 120 to 139 mmHg or diastolic blood pressure 80 to 89 mmHg during young adulthood is common and associated with coronary atherosclerosis that can lead to atherosclerosis later in life. The consequences of this disease cause millions of deaths across the world each year.

The cause of arteriosclerosis comes back to nutrition and lifestyle choices. Consumption of hydrogenated fats, sugars, lack of vitamins, minerals and antioxidants, stress and smoking all contribute towards the development of cardio vascular disease, infarction (heart attack) and strokes.

The chronic disease is characterized by lesions of the walls of arteries, the formation of fat plaques with the loss of their lumen. The atherosclerosis meets most often at men at the age of 50-60 years and at women is more senior 60 years, but recently among much younger (30-40 years). 

Low density lipoprotein is the main cause of harmful fat which is build up in arteries, therefore it is called as bad cholesterol in other words, if this level rises then there is a higher risk of heart attack.

Too much cholesterol causes many medical problems. Cholesterol is something that clogs the arteries in your heart. In addition, cholesterol when out of control could cause massive heart attacks, or series of mini strokes.

The most important cholesterol value is the HDL, or good cholesterol. Large studies of men and women have shown that a low HDL cholesterol may be the worst lipid risk factor for heart disease and stroke, and onset of dementia.

The nation’s pediatricians say we need to be more aggressive about lowering cholesterol in children. Ever since the 1980s, when one of the first major health studies showed conclusively that elevated cholesterol levels increased the risk of a heart attack. Fat, cholesterol, butter, cheese, eggs and especially cream have been vilified for their effect on cholesterol levels.

When it comes to cholesterol, most people think lower is better. But it isn’t so simple. While all the cholesterol you eat is the same, cholesterol in the blood travels in different types of LDL and HDL. High density lipoprotein (HDL) is considered  good cholesterol and low-density lipoprotein (LDL) called ‘bad’ cholesterol.

Cholesterol lowering drugs called statins have become a large part of pharmaceutical companies’ profits. Many of these drugs are coming under scrutiny for their expense and efficacy.

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Comments

bloggingzoom.com on 21 July, 2008 at 12:01 pm #

SEAS Trial Checks Merck-Schering-Plough…

New testing of drug combination Vytorin may reveal results that are unfavorable to Merck and Schering Plough. They are holding back their earnings statements until the study results are in. Why would it matter? If the test results are bad Vytorin sales…


SEAS Trial on 28 July, 2008 at 10:54 pm #

[...] SEAS Trial Checks Merck-Schering-PloughIn recent years, the spotlight has turned to the use of tocopherols in atherosclerosis as it relates to coronary and peripheral vascular disease. There is good evidence to suggest that vitamin E plays a beneficial role as adjunctive … [...]


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